Methyl [3,5-bis(trifluoromethyl)benzyl]({2'-methoxy-4-(trifluoromethyl)-5'-[1-(trifluoromethyl)vinyl]biphenyl-2-yl}methyl)carbamate → Methyl [3,5-bis(trifluoromethyl)benzyl]{[2'-methoxy-4-(trifluoromethyl)-5'-(2,2,2-trifluoro-1-methylethyl)biphenyl-2-yl]methyl}carbamate

Participants

Reaction Steps

The title compound from Step A (10 mg, 0.017 mmol) was hydrogenated at 1 atm in methanol using Pd/C as the catalyst. The solution was filtered through Celite then concentrated. The title compound was purified by preparative thin layer chromatography using 1:4 EtOAc:hexane.

Provenance & Evidence