Water → HCID 58565339, compound

Participants

Reaction Steps

Methyl 3-cyano-1-(3-fluorophenyl)-1H-indole-2-carboxylate (0.13 g, 0.44 mmol) was treated with 1.0 M lithium hydroxide in water (0.66 mL, 0.66 mmol) in methanol (3 mL) at room temperature for 3 hours. The reaction was diluted with 1 N HCl and extracted with EtOAc. The extracts were combined, washed with brine, dried over MgSO4 and concentrated to give the desired acid (0.12 g, 97%). LCMS calculated for C16H10FN2O2(M+H)+: m/z=281.1. Found: 281.1.

Provenance & Evidence