Ethyl Acetate → HCID 71231645, compound

Participants

Reaction Steps

Under cooling on ice, lithium aluminum hydride (657 mg, 17.3 mmol) was added to a solution of 2-[4-(4-fluorophenyl)piperazine-1-carbonyl]pyrrolo[1,2-a]quinazolin-5(4H)-one (the above Compound 1-1, 3.38 g, 8.66 mmol) in anhydrous tetrahydrofuran (75 mL). This reaction solution was stirred at room temperature for 2 hours. A small amount of ethyl acetate was added dropwise to the reaction solution, and then a saturated aqueous solution of sodium potassium tartrate tetrahydrate (100 mL), and water (100 mL) were added sequentially. The mixture was extracted twice with chloroform (100 mL). The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was collected by filtration with ethanol, to obtain the title compound (2.85 g, yield: 87%) as a pale yellow powder.

Provenance & Evidence