Cyclopropanecarbonyl chloride → HCID 71231639, compound

Participants

Reaction Steps

Diisopropylethylamine (0.11 mL, 0.63 mmol) and cyclopropane carbonyl chloride (30 μL, 0.33 mmol) were sequentially added to a solution of 2-(homopiperazine-1-carbonyl)pyrrolo[1,2-a]quinazolin-5(4H)-one hydrochloride (Compound 5-1, 70.0 mg, 0.20 mmol) in anhydrous N,N-dimethylformamide (0.50 mL), and the reaction solution was stirred overnight at room temperature. The reaction solution was diluted with ethyl acetate (20 mL), and washed sequentially with 0.1M sodium hydroxide aqueous solution (20 mL) and brine (20 mL). The aqueous layer was extracted twice with chloroform (20 mL), and combined with the ethyl acetate layer, and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the obtained residue was purified by silica gel column chromatography (ethyl acetate), to obtain the title compound (25.8 mg, yield: 34%) as a colorless powder.

Provenance & Evidence