Imidazole → 3-((Tert-butyldimethylsilyl)oxy)aniline

Participants

Reaction Steps

Chloro t-butyldimethylsilane (11 g, 72.98 mmol), 3-aminophenol (6.64 g, 60.81 mmol) and imidazole (5.38 g, 79.10 mmol) were added into 200 ml of dichloromethane. The mixture was stirred at room temperature for 15 hours. The reaction mixture was extracted using 200 ml of saturated ammonium chloride and 200 m of dichloromethane and the organic layer was washed twice using 200 ml of water. After concentrated under vacuum, the title compound (13.5 g, 99%) was obtained.

Provenance & Evidence