HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-amino-2-thiophenecarboxylate → Methyl 3-(formylamino)-2-thiophenecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-amino-2-thiophenecarboxylate | HCID 89652 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | Methyl 3-(formylamino)-2-thiophenecarboxylate | HCID 2777636 | 98.5% |
Reaction Steps
Formic acid 125 ml, and ammonium acetate (15.9 g, 207 mmol) were added to methyl 3-amino-2-thiophene carboxylate (25 g, 159.04 mmol) and the mixture was refluxed for 4 hours. After lowering the temperature to room temperature, the synthesized solid was washed with water and the title compound (29 g, 98%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062066B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-eba22fafb3644d51a230840e17a1e266 |
| Source note | uspto-grants-2015_06 |