Triphenylphosphine → HCID 54675631, compound

Participants

Reaction Steps

N-(3-methoxyphenyl)-6-(4-bromophenyl)thieno[3,2-d]pyrimidine-4-amine (0.26 g, 0.76 mmol) was dissolved in 5 ml of degassed dimethylformamide and added with 4-(2-hydroxyethyl)morpholine (0.12 ml, 0.92 mmol) and triphenylphosphine (241 mg, 0.92 mmol). The mixture was further added with DIAD (0.18 ml, 0.92 mmol) at 0° C. and stirred at room temperature for 15 hours. It was extracted with 50 ml saturated sodium bicarbonate and 50 ml of ethylacetate and the organic layer was washed with 50 ml of water twice, dried with magnesium sulfate and filtered. After concentration under vacuum, column chromatography (dichloromethane/methanol, 15/1) was done. The title compound (100 mg, 29%) was obtained as ivory colored solid.

Provenance & Evidence