Sodium Carbonate → HCID 89647654, compound

Participants

Reaction Steps

Na2CO3 (2.12 g, 20.04 mmol) was added to a suspension of 3-chloro-D-phenylalanine 9 (2.6 g, 10.02 mmol) in MeOH/H2O (8.3 mL/8.3 mL) at room temperature. Ethyl chloroformate (1.44 mL, 15.03 mmol) was added drop wise over 20 min via syringe pump and the reaction was stirred overnight. The reaction mixture was washed with Et2O (1×15 mL) and the aqueous layer was acidified to pH ˜5 with 2 M HCl (aq). The aqueous layer was extracted with EtOAc (2×30 mL). The combined organics were washed with brine, dried over MgSO4, filtered and concentrated to obtain the ethyl carbamate.

Provenance & Evidence