(Diethylamino)sulfur trifluoride → HCID 86729564, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (6-bromopyridin-3-yl)methanol (1.00 g, 5.32 mmol) in dichloromethane (25 mL) at 0° C. was added DAST (0.70 mL, 5.32 mmol) and the resulting solution was stirred at 0° C. for one hour. The mixture was washed with a saturated sodium bicarbonate solution and concentrated. Flash column separation using a 0-10% ethyl acetate/hexane gradient gave F-1 (0.37 g, 37%). LRMS (ES) (M+14)+: observed=190.0/192.0, calculated=190.0/192.0.

Provenance & Evidence