Diethyl Oxalate → Ethyl 2-hydrazinyl-2-oxoacetate

Participants

Reaction Steps

To a solution of diethyl oxalate (9-1) (6.0 g, 41.04 mmol) in alcohol (30 mL) was added hydrazine hydrate (2.4 mL, 49.26 mmol) dropwise at −20° C. After the addition was over, the solution was stirred for 30 min. The solution was filtered and the filtrate was evaporated to give the product as a white solid (3.0 g, 55%). The compound was used for the next step directly without further purification. LRMS (ESI) calculated M+H for C4H9N2O3: 133.1. Found: 133.3.

Provenance & Evidence