Hydrochloric Acid → HCID 86729580, compound

Participants

Reaction Steps

15-4 (40 mg, 0.06 mmol) was treated with HCl (4 M in 1,4-dioxane) (2 mL) and the mixture was stirred at room temperature for 6 h. Then it was concentrated, diluted with water (1 mL), and adjusted to pH 11 with aq NaOH (4 N). The resulting mixture was extracted with DCM (10 mL×4) and the organic layer was dried over Na2SO4, concetrated to afford the title compound (30 mg, 93%). 1H NMR (400 MHz, MeOD) δ 8.08 (s, 1H), 7.40 (d, J=7.8 Hz, 1H), 7.03 (d, J=8.0 Hz, 1H), 5.60 (s, 1H), 4.16 (dd, J=10.9, 6.5 Hz, 1H), 4.03 (dd, J=10.8, 7.5 Hz, 1H), 3.02 (s, 2H), 2.26 (s, 3H), 2.18 (s, 3H), 2.05-1.96 (m, 1H), 1.69 (d, J=6.2 Hz, 1H), 1.34 (s, 9H), 1.15-1.04 (m, 1H), 1.04-0.91 (m, 1H). LRMS (ES) calculated M+H for C22H28N6OS: 425.6. Found: 425.2.

Provenance & Evidence