Tert-butyl 3-(2-(((benzyloxy)carbonyl)amino)acetamido)azetidine-1-carboxylate → Tert-butyl 3-(2-aminoacetamido)azetidine-1-carboxylate

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Reaction Steps

To a flask containing tert-butyl 3-(2-(((benzyloxy)carbonyl)amino)acetamido)azetidine-1-carboxylate (9.26 g, 25.5 mmol) and a stirbar, was added 10% Pd/C (1.356 g, 1.27 mmol). The flask was evacuated and back filled with argon. Methanol (100 mL) was carefully added via syringe and the flask was evacuated with stirring. It was then back filled with hydrogen and stirred 2 days under a hydrogen balloon. After evacuation with stirring and back filling with argon, the catalyst was removed by filtration over Celite 521 and concentrated in vacuo to afford the product.

Provenance & Evidence