HCID 68003822, compound → HCID 68003854, compound

HRID 2175505Notes

Reaction equation

HRID 2175505 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH:11]3[NH:15][C:14](=[O:16])[CH:13]=[CH:12]3)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1>[Pd].CO>[O:1]1[C:5]2([CH2:6][CH2:7][CH:8]([CH:11]3[NH:15][C:14](=[O:16])[CH2:13][CH2:12]3)[CH2:9][CH2:10]2)[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 68003822HCID 68003822, compound

Product 1

HCID 68003854HCID 68003854, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a mixture of 5-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrrol-2(5H)-one (330 mg, 1.48 mmol), prepared in the previous step, and Palladium on Carbon (299 mg, 0.14 mmol, 5%, “Degussa, wet”) was carefully added methanol (30 mL). The reaction flask was evacuated, backfilled with hydrogen via balloon and stirred at room temperature overnight. The catalyst was removed by filtration and the filtrate concentrated in vacuo to afford the product.

Workup

  1. customThe reaction flask was evacuated
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate concentrated in vacuo
  4. customto afford the product

Sources & evidence

ORD record
ord-68b6f72136cb4b0998029ea3e3f5d919
Source dataset
uspto-grants-2015_06
Patent number
US09062048B2

Reaction notes

Loading…