反应详情

8-(oxiran-2-yl)-1,4-dioxaspiro[4.5]decane (202 mg, 1.10 mmol), prepared in the previous step, in DCM (20 mL) was dissolved in sodium methoxide solution (10 mL, 5 mmol, 0.5 M). The mixture was stirred, heating to reflux under argon overnight and then cooled to ambient temperature and concentrated in vacuo. After addition of saturated ammonium chloride solution and extraction with ethyl acetate, the organic layers were concentrated in vacuo and the residue was purified by flash chromatography (silica gel, 0-50% ether) to afford the product.

1. temperatureheating
2. temperatureto reflux under argon overnight
3. concentrationconcentrated in vacuo
4. additionAfter addition of saturated ammonium chloride solution and extraction with ethyl acetate
5. concentrationthe organic layers were concentrated in vacuo
6. customthe residue was purified by flash chromatography (silica gel, 0-50% ether)
7. customto afford the product