HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-(2-((2,6-bis(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate → N-(azetidin-3-yl)-2-((2,6-bis(trifluoromethyl)quinolin-4-yl)amino)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-(2-((2,6-bis(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate | HCID 86660461 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(azetidin-3-yl)-2-((2,6-bis(trifluoromethyl)quinolin-4-yl)amino)acetamide | HCID 86660462 | — |
Reaction Steps
A solution of tert-butyl 3-(2-((2,6-bis(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate (291 mg, 1.04 mmol) in dry dioxane (5 mL), prepared in Step C above, was de-protected as described in example to afford the product. ESI-MS (m/z): Calcd. For C16H14F3N4O: 392.11. found: 393 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062048B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-1f16e65ee95a4d309d40bf20780602e7 |
| Source note | uspto-grants-2015_06 |