HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 217553Generated: October 31, 2026
Ethyl Acetate → 2-(2-{2-[2-(2-Fluoro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-1,1-dimethoxy-ethane
https://huagongshe.com/reaction/217553
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | Methanesulfonic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester | HCID 59236870 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(2-{2-[2-(2-Fluoro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-1,1-dimethoxy-ethane | HCID 59236863 | 93% |
Reaction Steps
A mixture of the sulfonate (Compound 6) (75 mg, 0.21 mmol) and TBAF (1.1 M in THF, 573 μl, 0.63 mmol) in acetonitrile (8 ml) was heated at 90° C. for 30 minutes. TLC (ethyl acetate) monitoring showed the reaction was completed. After cooling to ambient and evaporation of the solvent the residue was flashed (Ethyl acetate) to afford the product (56 mg, 93%) as colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08197793B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-2ddeb037ade64fdc9a47cb1ebdf2557e |
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| Source note | uspto-grants-2012_06 |
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