HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1,4-Dioxaspiro(4.5)decan-8-yl methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1,4-Dioxaspiro(4.5)decan-8-ol | HCID 567352 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1,4-Dioxaspiro(4.5)decan-8-yl methanesulfonate | HCID 14966741 | — |
Reaction Steps
1,4-dioxaspiro[4.5]decan-8-ol (1 g, 6.32 mmol) and triethylamine (1.3 mL, 9.48 mmol) taken in anhydrous THF and treated with methanesulfonyl chloride (0.73 mL, 9.48 mmol). Stirred for 18 h. Diluted with water and extracted with EtOAc. The ethyl acetate layer washed with sat NaCl, dried over Na2SO4 and evaporated to give the expected product. Used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062048B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-0076f010d55c4cfbb8a2e587d6ede4eb |
| Source note | uspto-grants-2015_06 |