HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2175552Generated: October 31, 2026
2-Pyridone → 1-(1,4-dioxaspiro[4.5]decan-8-yl)pyridin-2(1H)-one
https://huagongshe.com/reaction/2175552
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Pyridone | HCID 8871 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-pyridin-3-ol | HCID 58562515 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(1,4-dioxaspiro[4.5]decan-8-yl)pyridin-2(1H)-one | HCID 58562900 | — |
Reaction Steps
A solution of 4-dioxaspiro[4.5]decan-8-yl methanesulfonate (497 mg, 2 mmol) from example 1, step A and pyridin-2(1H)-one (200 mg, 2 mmol) in DMF was treated with Cs2CO3 (1 g, 3 mmol) and heated at 80° C. for 18 h. DMF was removed under vacuum and the residue was purified by silica column chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09062048B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-26f36a717b94495ba49cfa09f80105a0 |
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| Source note | uspto-grants-2015_06 |
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