反应详情

A methanolic solution of methyl 2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetate (241 mg, 0.58 mmol) from above step G was cooled in an ice bath and treated with a solution of 1N NaOH (2.88 ml, 2.88 mmol). The solution was stirred for 4 h (monitored with TLC for completion), MeOH evaporated under vacuum (no heat), and the residue treated with 1N HCl and extracted with EtOAc. The EtOAc layer was washed with saturated NaCl, dry over Na2SO4 and evaporated to give the title compound.

1. customevaporated under vacuum (
2. temperatureno heat), and the residue
3. additiontreated with 1N HCl
4. extractionextracted with EtOAc
5. washThe EtOAc layer was washed with saturated NaCl
6. dry with materialdry over Na2SO4
7. customevaporated