4-Methylcyclohexanone → HCID 68004063, compound

Participants

Reaction Steps

Reaction of 4-methylcyclohexanone with N-(azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide (as prepared in Example 1 Step G) in the presence of TEA and NaBH(OAc)3 as described in Example 1, Step H afforded the product. 1H NMR (CHLOROFORM-d) δ: 8.61 (s, 1 H), 8.11 (s, 1 H), 8.04 (t, J=4.9 Hz, 1 H), 7.71-7.82 (m, 2 H), 6.80 (d, J=7.3 Hz, 1 H), 4.59 (sxt, J=6.4 Hz, 1 H), 4.27 (d, J=5.3 Hz, 2 H), 3.60 (t, J=7.3 Hz, 2 H), 2.95 (t, J=6.6 Hz, 2 H), 2.15 (br. s., 1 H), 1.49-1.61 (m, 1 H), 1.27-1.49 (m, 8H), 0.91 (d, J=6.8 Hz, 3 H); ESI-MS (m/z): Calcd. For C21H26F3N5O: 421.21. found: 422 (M+H).

Provenance & Evidence