Sodium triacetoxyborohydride → HCID 86660466, compound

Participants

Reaction Steps

Reaction of ethyl 4-(trifluoromethyl)cyclohexanone with N-(azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide (as prepared in Example 1 Step G) in the presence of TEA and NaBH(OAc)3 as described in Example 1, Step H afforded the product. 1H NMR (CHLOROFORM-d) δ: 8.60 (s, 1 H), 8.21 (t, J=5.4 Hz, 1 H), 8.12 (s, 1 H), 7.71-7.81 (m, 2 H), 6.92 (d, J=7.8 Hz, 1 H), 4.49-4.66 (m, 1 H), 4.28 (d, J=5.6 Hz, 2 H), 3.57 (t, J=7.5 Hz, 2 H), 2.85-3.00 (m, 2 H), 2.31 (t, J=3.2 Hz, 1 H), 1.89-2.14 (m, 2 H), 1.53-1.78 (m, 5 H), 1.28-1.42 (m, 2 H); ESI-MS (m/z): Calcd. For C21H23F6N5O: 475.18. found: 476 (M+H).

Provenance & Evidence