Hydrochloric Acid → HCID 68003419, compound

Participants

Reaction Steps

A solution of N-(1-1,4-dioxaspiro[4.5]decan-8-ylpropyl)-1,1,1-trifluoromethanesulfonamide (as prepared in the previous step, 47 mg, 0.14 mmol, 1.00 equiv) in CH3CN (5 mL) and HCl (2M, 1 mL) was stirred for 2 h at room temperature. The resulting mixture was concentrated under vacuum. The residue was diluted with 10 mL of aq. sodium bicarbonate (1M). The resulting solution was extracted with 2×20 mL of dichloromethane. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under vacuum to give the title compound as a yellow oil.

Provenance & Evidence