Azane;hydrate → HCID 71217685, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-chloro-5-iodo-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine (16) (4.0 g, 10.0 mmol) in dioxane (80 mL) and NH3.H2O (40 mL) was sealed in a reaction vessel and heated to 120° C. for 1 hr. After cooling to r. t., the reaction mixture was concentrated under reduced pressure to afford 5-iodo-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (17) (quant. yield) as a yellow solid which was directly used in next step. LC-MS (ESI): m/z (M+1) 381.6.

Provenance & Evidence