Trifluoroacetic acid → HCID 86719396, compound

Participants

Reaction Steps

(R)-(5-((4-(4-Amino-6-methyl-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)methyl pivalate (84) (121 mg, quant. yield) was prepared by treating (R)-tert-butyl 3-(4-amino-6-methyl-5-(4-((1-(pivaloyloxymethyl)-1H-1,2,3-triazol-5-yl)methoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate (83) (188 mg, 0.31 mmol) with TFA in a similar manner as described in Example 1. LC-MS (ESI): m/z (M+1) 505.0.

Provenance & Evidence