3',4'-Dimethoxycinnamic acid → (2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl chloride

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3-(3,4-dimethoxyphenyl)acrylic acid (416 mg 2 mmol) in toluene (10 mL) was added thionyl chloride (1.45 mL, 20 mmol). The solution was heated at 50° C. for 1 hour and then the solvent was removed under reduced pressure to give (E)-3-(3,4-dimethoxyphenyl)acryloyl chloride, which was used directly in the next step without purification.

Provenance & Evidence