反应详情

To a stirred solution of 6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one (3.09 g, mmol) in MeOH (50 mL) was added NaBH4 (680 mg, 18 mmol) portion wise over 0.5 hour. The resulting mixture was stirred at room temperature overnight. The reaction was quenched with 1N HCl, diluted with water and extracted with DCM. The combined organic phase was washed with brine, dried over sodium sulfate and the solvent was removed under reduced pressure to afford 6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-ol as a yellow oil (2.9 g, 93%). LC-MS (ES-API); rt 7.96 min; m/z calculated for C12H16O3 [M+Na]+ 231.1, found 231.1.

1. customThe reaction was quenched with 1N HCl
2. additiondiluted with water
3. extractionextracted with DCM
4. washThe combined organic phase was washed with brine
5. dry with materialdried over sodium sulfate
6. customthe solvent was removed under reduced pressure