反应详情

温度

150 °C

6-Fluoro-2-methoxy-3-(oxiran-2-yl)benzonitrile (1.4 g, 7.3 mmol) and (S)-4-N-BOC-2-hydroxymethylpiperazine (3.13 g, 14.5 mmol) were suspended in ethanol (15 mL) then heated in a microwave apparatus for 60 min at 150° C. The reaction mixture was cooled and evaporated to dryness. The residue was purified by chromatography through a 40 g Redi-sep column and eluting with 5% MeOH/95% EtOAc to yield the title compound: LC-MS: M+1=410;

1. temperatureThe reaction mixture was cooled
2. customevaporated to dryness
3. customThe residue was purified by chromatography through a 40 g Redi-sep column
4. washeluting with 5% MeOH/95% EtOAc