Water → 2-Bromo-5-fluoroanisole

Participants

Reaction Steps

A solution of 2-bromo-5-fluorophenol (15 g, 79 mmol) in 125 mL of anhydrous DMF was added K2CO3 (17.0 g, 138 mmol) and MeI (14.0 g, 102 mmol) under cooling, then the reaction was stirred at room temperature for 3 hours. The mixture was poured to water, extracted with diethyl ether, washed with water and brine, dried over anhydrous Na2SO4 and concentrated to give 1-bromo-4-fluoro-2-methoxybenzene.

Provenance & Evidence