HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3-methyl-2-thiophenecarbonitrile → HCID 86727075, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3-methyl-2-thiophenecarbonitrile | HCID 21717671 | — |
| Reactant | Potassium vinyltrifluoroborate | HCID 23679353 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86727075 | HCID 86727075 | — |
Reaction Steps
A mixture of 4-bromo-3-methylthiophene-2-carbonitrile (3.00 g, 14.8 mmol), potassium vinyltrifluoroborate (2.40 g, 17.8 mmol) and Pd(dppf)Cl2 (0.5 g) in 30 mL of EtOH and 30 mL of TEA was refluxed under Ar for 4 hours. The reaction mixture was concentrated, and the residue was purified by column chromatography (petrol ether: EtOAc=50:1) to afford 4-ethenyl-3-methylthiophene-2-carbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062070B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-c7134f5583e944e6a5fee4682a7bc6b9 |
| Source note | uspto-grants-2015_06 |