HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium vinyltrifluoroborate → HCID 86727086, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium vinyltrifluoroborate | HCID 23679353 | — |
| Reactant | 4-Bromo-2-fluoro-3-methylbenzonitrile | HCID 59556913 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86727086 | HCID 86727086 | — |
Reaction Steps
A mixture of 4-bromo-2-fluoro-3-methylbenzonitrile (7.00 g, 32.7 mmol), potassium vinyltrifluoroborate (5.3 g, 39 mmol) and Pd(dppf)Cl2 (0.5 g, 0.7 mmol) in 70 mL of EtOH and 30 mL of TEA was refluxed under Ar for 4 hours. Concentrated, the residue was purified by column chromatography (petrol ether:EtOAc=10:1) to afford 4-ethenyl-2-fluoro-3-methylbenzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062070B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-957b214c939c4e36af44a59a50adafc2 |
| Source note | uspto-grants-2015_06 |