反应详情

[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-carbamic acid benzyl ester (7, 800 mg, 1.81 mmol) was added to 15.00 mL of 10 M sodium hydroxide and warmed to reflux overnight. The reaction mixture was diluted with 30 mL of water and extracted with ethyl acetate. The organic layer was separated, dried, filtered and the filtrate concentrated under vacuum to give the desired compound (8, 450 mg, 81%).

1. temperaturewarmed
2. temperatureto reflux overnight
3. extractionextracted with ethyl acetate
4. customThe organic layer was separated
5. customdried
6. filtrationfiltered
7. concentrationthe filtrate concentrated under vacuum