2-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-5-carboxylic acid → 2-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-6-carboxylic acid

HRID 2175904Notes

Reaction equation

HRID 2175904 reaction equation
[N:1]1([C:6]2[N:7]=[CH:8][C:9]3[CH2:14][CH:13]([C:15]([O:17]C)=[O:16])[CH2:12][C:10]=3[N:11]=2)[CH:5]=[N:4][N:3]=[N:2]1.N1(C2N=C3CCC(C(O)=O)C3=CC=2)C=NN=N1>>[N:1]1([C:6]2[N:7]=[CH:8][C:9]3[CH2:14][CH:13]([C:15]([OH:17])=[O:16])[CH2:12][C:10]=3[N:11]=2)[CH:5]=[N:4][N:3]=[N:2]1

Participants

3

Reactant 2

HCID 675172942-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-5-carboxylic acidHCID 86727101Methyl 2-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-6-carboxylate

Product 1

HCID 867271022-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-6-carboxylic acid

Procedure

The title compound was prepared from methyl 2-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-6-carboxylate in an analogous fashion to that described in Step F of the synthesis of 2-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-5-carboxylic acid.

Sources & evidence

ORD record
ord-eeb90a7e098241e4ba83029b32277983
Source dataset
uspto-grants-2015_06
Patent number
US09062070B2

Reaction notes

Loading…