反应详情

温度

150 °C

To the title compound of step B (509 mg, 2.2 mmol) and the title compound of step C (1.1 g, 2.9 mmol) in PhCH3 (6.6 mL) was added Pd(PPh3)4 (225 mg, 0.2 mmol). The reaction was degassed with N2 and heated at 150° C. for 1.5 h using microwave reactor. The reaction was cooled to rt, diluted with H2O and extracted with EtOAc. The organic layer was dried (MgSO4). Purification via silica gel chromatography (0-100% EtOAc in heptane) gave the title compound (101 mg, 18%). MS (ESI) mass calcd. for C14H14N2O2, 242.3; m/z found 243 [M+H]+.

1. customThe reaction was degassed with N2
2. temperatureThe reaction was cooled to rt
3. additiondiluted with H2O
4. extractionextracted with EtOAc
5. dry with materialThe organic layer was dried (MgSO4)
6. customPurification via silica gel chromatography (0-100% EtOAc in heptane)