HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 90411799, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid | HCID 53260165 | — |
| Reactant | HCID 90412474 | HCID 90412474 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ammonia methanol | HCID 21705897 | 1% |
| Product | HCID 90411799 | HCID 90411799 | 46% |
Reaction Steps
To the title compound of Step A in DMF was added TEA, 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid and HATU. After 18 h, H2O was added and the mix extracted with EtOAc (2×). The combined organics were washed with brine and dried (Na2SO4). Silica gel chromatography (1-7% 2M NH3/MeOH in DCM) gave the title compound (371 mg, 46%). MS (ESI) mass calcd. for C17H20N4O2, 312.2; m/z found 313.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062078B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-ce5ac13fa3fa494d9cd047bd83dad735 |
| Source note | uspto-grants-2015_06 |