2-(Methylamino)ethanol → HCID 60740715, compound

Participants

Reaction Steps

To a mixture of 6.2 mL of 2-(methylamino)ethanol, 6.48 g of sodium hydrogen carbonate, 60 mL of THF, and 30 mL of water was added dropwise 10 mL of ethyl succinyl chloride over 30 minutes under ice cooling, followed by stirring for 3 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=11:4), thereby obtaining 12.0 g of ethyl 4-[(2-hydroxyethyl)(methyl)amino]-4-oxobutanoate.

Provenance & Evidence