N,N'-Diisopropylethylenediamine → HCID 90370189, compound

HRID 2175993Notes

Reaction equation

HRID 2175993 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:39]=[CH:40][CH:41]=1)[C:6]([NH:8][C:9]1[S:10][C:11]2[CH2:38][CH2:37][CH2:36][CH2:35][C:12]=2[C:13]=1[C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]2[CH:34]=[CH:33][C:28]([C:29]([O:31][CH3:32])=[O:30])=[CH:27][CH:26]=2)=[CH:19][CH:18]=1)=[O:15])=[O:7].[CH:42]([NH:45][CH2:46][CH2:47][NH:48][CH:49]([CH3:51])[CH3:50])([CH3:44])[CH3:43]>>[CH:42]([N:45]([CH2:2][C:3]1[CH:4]=[C:5]([CH:39]=[CH:40][CH:41]=1)[C:6]([NH:8][C:9]1[S:10][C:11]2[CH2:38][CH2:37][CH2:36][CH2:35][C:12]=2[C:13]=1[C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]2[CH:34]=[CH:33][C:28]([C:29]([O:31][CH3:32])=[O:30])=[CH:27][CH:26]=2)=[CH:19][CH:18]=1)=[O:15])=[O:7])[CH2:46][CH2:47][NH:48][CH:49]([CH3:51])[CH3:50])([CH3:44])[CH3:43]

Participants

3

Reactant 2

HCID 77628N,N'-DiisopropylethylenediamineHCID 90370193HCID 90370193, compound

Product 1

HCID 90370189HCID 90370189, compound

Procedure

By using 250 mg of methyl 4-[2-(4-{[(2-{[3-(chloromethyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenyl)ethyl]benzoate and 0.25 mL of N,N′-diisopropylethylenediamine as starting materials, the reaction similar to Preparation Example 9 was performed, thereby obtaining 220 mg of methyl 4-[2-(4-{[(2-{[3-({isopropyl[2-(isopropylamino)ethyl]amino}methyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenyl)ethyl]benzoate.

Workup

  1. customthe reaction
  2. customsimilar to Preparation Example 9

Sources & evidence

ORD record
ord-0577b44a9748477c82d70aa5280f1823
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

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