Tetrabutylammonium Fluoride → HCID 90370238, compound

Participants

Reaction Steps

To a mixture of 830 mg of methyl 4-[2-(4-{[(2-{[3-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenyl)ethyl]benzoate and 10 mL of THF was added 1.5 mL of tetrabutylammonium fluoride (TBAF) (1.0 M THF solution) under ice cooling, followed by stirring for 4 hours at room temperature and then overnight at 50° C. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (10% methanol/chloroform), thereby obtaining 540 mg of methyl 4-[2-(4-{[(2-{[3-(2-hydroxyethyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenyl)ethyl]benzoate.

Provenance & Evidence