HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 90370380, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 6993579 | HCID 6993579 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 90370366 | HCID 90370366 | — |
| Product | HCID 90370380 | HCID 90370380 | 81.6% |
Reaction Steps
By using 200 mg of methyl 4-[2-(4-{[(2-{[3-({[2-(methylamino)ethyl](pentan-3-yl)amino}methyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenyl)ethyl]benzoate, 60 mg of monoethyl adipate, and 0.10 mL of N-ethyl-N-isopropylpropan-2-amine as starting materials, and using 142 mg of O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) as a condensing agent, the reaction similar to Preparation Example 27 was performed, thereby obtaining 200 mg of methyl 4-(2-{4-[({2-[(3-{[{2-[(6-ethoxy-6-oxohexanoyl)(methyl)amino]ethyl}(pentan-3-yl)amino]methyl}benzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophen-3-yl}carbonyl)amino]phenyl}ethyl)benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062032B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-1832dba45dd84c97926ae788e893ad53 |
| Source note | uspto-grants-2015_06 |