Hydrochloric Acid → HCID 90370333, compound

Participants

Reaction Steps

A mixture of 1.9 g of ethyl 2-{[{2-[(4-tert-butoxy-4-oxobutanoyl)(methyl)amino]ethyl}(pentan-3-yl)amino]methyl}isonicotinate, 8.2 mL of a 1.0 M aqueous sodium hydroxide solution, 8.0 mL of methanol, and 16 mL of THF was stirred overnight at room temperature. The mixture was neutralized using 1.0 M hydrochloric acid, water was added thereto, followed by extraction with chloroform-methanol. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure, thereby obtaining 1.5 g of 2-{[{2-[(4-tert-butoxy-4-oxobutanoyl)(methyl)amino]ethyl}(pentan-3-yl)amino]methyl}isonicotinic acid.

Provenance & Evidence