Methyl 4-(bromomethyl)benzoate → HCID 90370130, compound

HRID 2176029Notes

Reaction equation

HRID 2176029 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[C:15]3[CH2:16][CH2:17][CH2:18][CH2:19][C:14]=3[S:13][C:12]=2[NH:20][C:21](=[O:35])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)[CH:23]=2)=[O:10])=[CH:4][CH:3]=1.Br[CH2:37][C:38]1[CH:47]=[CH:46][C:41]([C:42]([O:44][CH3:45])=[O:43])=[CH:40][CH:39]=1>>[N:29]1([CH2:28][C:24]2[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=2)[C:21]([NH:20][C:12]2[S:13][C:14]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[C:11]=2[C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([O:1][CH2:37][C:38]3[CH:47]=[CH:46][C:41]([C:42]([O:44][CH3:45])=[O:43])=[CH:40][CH:39]=3)=[CH:7][CH:6]=2)=[O:10])=[O:35])[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1

Participants

3

Reactant 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 90370057HCID 90370057, compound

Product 1

HCID 90370130HCID 90370130, compoundYield 87.8%

Procedure

By using 169 mg of N-(4-hydroxyphenyl)-2-{[3-(morpholin-4-ylmethyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide and 95 mg of methyl 4-(bromomethyl)benzoate, 193 mg of methyl 4-[(4-{[(2-{[3-(morpholin-4-ylmethyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenoxy)methyl]benzoate was obtained by the method similar to Preparation Example 30.

Sources & evidence

ORD record
ord-7f79b83f88474f289caef9c98324d574
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

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