2-Chloro-pyrimidine-5-carboxylic acid ethyl ester → HCID 90370169, compound

Participants

Reaction Steps

By using 250 mg of methyl 4-{2-[4-({[2-({3-[(cyclopropylamino)methyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoate and 153 mg of ethyl 2-chloropyrimidine-5-carboxylate as starting materials, the reaction similar to Preparation Example 30 was performed, thereby obtaining 307 mg of ethyl 2-{cyclopropyl[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl}-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)benzyl]amino}pyrimidine-5-carboxylate.

Provenance & Evidence