HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-bromobutyrate → HCID 89534607, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | Methyl 4-{2-[4-({[2-({3-[(cyclopropylamino)methyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoate | HCID 90370229 | — |
| Product | HCID 89534607 | HCID 89534607 | 56.4% |
Reaction Steps
By using 300 mg of methyl 4-{2-[4-({[2-({3-[(cyclopropylamino)methyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoate and 289 mg of ethyl 4-bromobutyrate, the reaction similar to Preparation Example 30 was performed, thereby obtaining 201 mg of methyl 4-(2-{4-[({2-[(3-{[cyclopropyl(4-ethoxy-4-oxobutyl)amino]methyl}benzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophen-3-yl}carbonyl)amino]phenyl}ethyl)benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062032B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-f1773b3a86b64888acbd8d9a1f49b829 |
| Source note | uspto-grants-2015_06 |