Hydrogen chloride-ethyl acetate → HCID 90370272, compound

HRID 2176037Notes

Reaction equation

HRID 2176037 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][CH2:6][C:7]([N:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)=[O:8])[CH3:2].[ClH:23].C(OCC)(=O)C>>[ClH:23].[O:8]=[C:7]([N:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[CH2:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:22]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 90370218HCID 90370218, compound

Product 1

HCID 90370272HCID 90370272, compound

Procedure

By using 1.2 g of tert-butyl 4-(4-ethoxy-4-oxobutanoyl)piperazine-1-carboxylate and 1.0 mL of 4.0 M hydrogen chloride/ethyl acetate solution, the reaction similar to Preparation Example 35 was performed, thereby obtaining 900 mg of ethyl 4-oxo-4-(piperazin-1-yl)butanoate hydrochloride.

Workup

  1. customthe reaction
  2. customsimilar to Preparation Example 35

Sources & evidence

ORD record
ord-cb7a12a56e5f46ebb07a64e5b57ae743
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

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