Hydrochloric Acid → HCID 71519598, compound

Participants

Reaction Steps

To a mixture of 306 mg of N-cyclopropyl-N-[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)benzyl]glycine hydrochloride and 5.0 mL of dichloromethane were added 0.182 mL of triethylamine, 91 mg of methyl N-methylglycinate hydrochloride, 125 mg of WSC.hydrochloride and 88 mg of HOBt, followed by stirring for 15 hours at room temperature. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine and then dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography, thereby obtaining 152 mg of methyl N-cyclopropyl-N-[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)benzyl]glycyl-N-methylglycinate.

Provenance & Evidence