Thionyl Chloride → HCID 89534606, compound

Participants

Reaction Steps

By a method similar to Preparation Example 37, 197 mg of methyl 4-(2-{4-[({2-[(3-{[(2-hydroxyethyl)(pentan-3-yl)amino]methyl}benzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophen-3-yl}carbonyl)amino]phenyl}ethyl)benzoate was reacted with 0.10 mL of thionyl chloride, and then the resultant was reacted with 325 mg of ethyl isonipecotate, thereby obtaining 206 mg of ethyl 1-(2-{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)benzyl](pentan-3-yl)amino}ethyl)piperidine-4-carboxylate.

Provenance & Evidence