Ethyl 4-(cyclopropylamino)cyclohexanecarboxylate → HCID 90370059, compound

Participants

Reaction Steps

By using 400 mg of 2-{[3-(chloromethyl)benzoyl]amino}-N-[4-(pyridin-4-ylmethyl)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide and 819 mg of ethyl 4-(cyclopropylamino)cyclohexanecarboxylate, the alkylation similar to Preparation Example 30 was performed, and then hydrolysis was performed under the conditions similar to Example 5, thereby obtaining 261 mg of 4-(cyclopropyl{3-[(3-{[4-(pyridin-4-ylmethyl)phenyl]carbamoyl}-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]benzyl}amino)cyclohexane carboxylic acid dihydrochloride.

Provenance & Evidence