Ammonium Chloride → HCID 90370185, compound

Participants

Reaction Steps

A mixture of 0.07 mL of lithium hexamethyldisilazide (1.0M in THF) and 0.2 mL of THF was added to a mixture of 11.5 mg of 2-[3-(morpholin-4-ylmethyl)phenyl]-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one, 4.9 mg of 5-cyclopropyl-1,3,4-thiadiazol-2-amine, and 0.8 mL of THF, followed by stirring overnight at room temperature. Chloroform and a saturated aqueous ammonium chloride solution were added to the reaction mixture, and the organic layer was separated. After the solvent was removed under reduced pressure, the obtained residue was purified, thereby obtaining 11.4 mg of N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{[3-(morpholin-4-ylmethyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide.

Provenance & Evidence