Ethyl Acetate → HCID 86705072, compound

Participants

Reaction Conditions

Reaction Steps

280 g (1.31 mol) of (3Z)-3-(5,5-dimethyl-2-oxo-1,3-dioxolan-4-ylidene)propyl acetate (exo-VC-OAc), 1307 g (13.1 mol) of ethyl acetate, 0.28 g of 4-methoxyphenol (MeHQ) and 84 g (30% by weight) of Novozym® 435 from Novozymes were combined. The mixture was stirred at 40° C. for 24 h. The mixture was filtered and washed through with acetone, and the solvent was removed at 40° C. on a rotary evaporator. This gave 276.7 g of the product of the title compound with a purity of 92.4% (GC analysis).

Provenance & Evidence