HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Iodo-1H-pyrrolo[2,3-b]pyridine → Propane-1-sulfonic acid [2-fluoro-3-(5-iodo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Iodo-1H-pyrrolo[2,3-b]pyridine | HCID 24229214 | — |
| Reactant | Propane-1-sulfonic acid (2-fluoro-3-formyl-phenyl)-amide | HCID 58086814 | — |
| Reactant | 2-Methyl-propane-1-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide | HCID 58316930 | — |
| Product | Propane-1-sulfonic acid [2-fluoro-3-(5-iodo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-phenyl]-amide | HCID 59569593 | — |
Reaction Steps
was prepared similarly to the protocol of Scheme 10, replacing 5-bromo-1H-pyrrolo[2,3-b]pyridine 55 with 5-iodo-1H-pyrrolo[2,3-b]pyridine 24 and 2-methyl-propane-1-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 59 with propane-1-sulfonic acid (2-fluoro-3-formyl-phenyl)-amide 67 in step 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198273B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-81c39a3099874acdb57423d1da47f238 |
| Source note | uspto-grants-2012_06 |