HCID 66668749, compound → HCID 66664953, compound

Participants

Reaction Steps

tert-butyl 4-(2-(3-nitrophenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate (220, 0.480 mmol, 1.0 equiv) is dissolved in 5 mL methanol. To the solution is added palladium on carbon (51.1 mg). The reaction is stirred under an atmosphere of hydrogen for 3 h. Upon completion, the mixture is filtered through celite and concentrated in vacuo to give crude tert-butyl 4-(2-(3-aminophenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate as a yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.37 (s, 1H), 7.20-7.29 (m, 1H), 7.13 (d, J=7.83 Hz, 1H), 6.83 (dd, J=7.63, 1.76 Hz, 1H), 5.46 (s, 1H), 3.87 (s, 2H), 3.45-3.65 (m, 8H), 1.48 (m, 9H);

Provenance & Evidence